I am tossed up on which rifle to buy the 22-250 or the 243. I would be using it on coyotes and maybe whitetail deer. But more for coyotes because I have larger rifles for the deer. My shots would max out at about 100-175 yards. Any and all advice is welcome thank you

You might also consider a .223.  I have both 22-250 and 223 and I find myself  using the 223 more.  The 22-250 sure is a flat shooter but at the distance that you stated the 223 would be great.  Another bonus is the ammo is more plentiful and cheaper.  Good luck with what ever you choose.

At the stated range I would consider the .223 as well, also you may want to look into a .204 as well as they do a number on yotes at that range. The .223 will be cheaper to shoot as well unless you reload then the point is mute. Now as you stated you may throw deer in there as well and if so I would opt for the .243.

Holy big picture batman.

I'd say the 22-250 because your gonna say under 200 yards, then when you start driving tacks at that distance, your gonna want to challenge yourself and start really getting out there, thats when the 22-250 will make you happier.

Got the BIG pix!! 243 hands down! I own several 223, 22-250, and 243. For a multy purpose yote/deer gun none better. If you hand load 55 to 100 grain. If not, find an 80-90 grain that shoots well.

Ask a dozen folks, and get basically a dozen answers. I used a mini-14 in .223 for years, but swithced to a .220 swift, after considering a .222-250. Of course mine is a Ruger, and since the .22-250 wasn't, the Ruger immediately had an edge. It's all a matter of personal choice, and what you feel comfortable shooting, at the ranges you intend to hunt. Regardless of what you decide, good luck!!!!!

Used a 22-250 on a deer broadside. bullet hit about 2 inches above the heart, ( friend shooting) the deer imploded so bad that the paunch stuff was found under the hide past the shoulder down to the knee. Way messy. For yotes the 22-250 is more than enough gun at the ranges you stated. The 243 is a lil better in windy areas.

Over the past 40 years I have used them all. The 22-250 has always been a favorite of mine for coyotes and prairie dogs, especially when you get out from 200-400 yards. Unfortunately, we get frequent winds up here in Montana, and you get alot of wind drift with a smaller projectile. Load up a 243 with some 70gr bullets and some 4064, and that isn't so much a factor. That being said, between a 223 and a 22-250, the 250 is a better performer, but IMHO most people can't shoot the difference, so a 223 would not be a bad choice.

.22-250 = dedicated predator caliber

.243 = dual purpose predator/deer caliber

I'll second SDOWLING here. .22-250 varmints only, and .243 = more versatility.

If I was gonna use it for deer, I'd have to agree with the .243.

You said you "have larger rifles"for deer. Buy the varmit rifle!!!!! Play time is important. No brainer

I have to agree with prairiedogger.

i have a 243 and 22-250 i have shot them side by side out to 500 yards the 243 when loaded with light grain equal to the 22-250 it beats it hands down plus you can jump up to 80 and 100 for white tail just a tid bit of info for ya

Just my 2cents worth, If you go with the .243 use speers 70gr. tnt bullets . Awsome!
Ive shoot .223 in three different guns - very happy with results
ive shoot a friends 22-250- very nice indeed
Ive shoot .204 and really like it.

The .243 will cost abit more to shoot but they will all do fine for varmits. If your only buying one rifle................ the 243 is the way to go.

Projectile and twist would be of more concern to me than headstamp. Lotsa good stuff out there that works well. Particularly for the handloader and knowledgeable rifleman.
Right now where I considering a dual varmint/deer caliber I would lead towards a .257 in projectile. Several cases exist to fuel the fire but I think the 250 Savage is a very efficient case for such a purpose. A 87 gr .257 at 3100 fps is a real good dual purpose bullet from the savage case.
Where I to use a .224 caliber centerfire tube it would most certainly be twisted fast(8-9 in) and I would run heavy bullets or BarnesTTSX or similar for the deer chores.
The 22-250 will give you about a 100 yard edge distance wise over the .223 but under 200 yards you wont see a lot of performance on yotes when equal bullet weights are used. Past that distance the bigger cases and heavier bullets will win in both performance and wind bucking abilities.
One of my favorite dual purpose cartridges is a .25 Souper, a 243 case necked up to 257.
A .243 with 80 grain bullets and lighter isn't much of an advantage over the fast twist 22-250 with equal bullet weights.

ive used 223 and 243...i would say 243 wiht hornady vmax...puts them in the dirt where they stand

I simply love my 22-250 and have thought of taking a whitetail with a handloaded barnes bullet but i figure i owe it to the deer to kill it efficiently as possible so as a rule i don't use it on deer. If you just want to be prepared if a nice buck stepped out while yote hunting then  a 243 is a better choice, with a deer round in your pocket.  Either way I'd consider using your deer rifle on yote hunting as it is good "practice" in the off season, unless you want the pelt.  
Given the range you stated I would look hard at an Ar rifle in 223, they are just a BLAST to shoot and ammo is cheap, as well even the carbines are accurate at descent ranges of 200-250 yds, easy on the arms too as they range about 6 lbs or so in weight.

The problem with most DUAL purpose calibers is that most folks choose light weight bullets for varmints and heavier weight bullets for deer size game. This approach will require sight changes between the two different bullet weights. The bullet that works best for one application likely will not be the best for the other application. The best senario would be a dual purpose cartridge that could effectively use one weight bullet for both applications. The bullet selection is there in several cases. The notion that the 22-250 is not an effective deer slayer is incorrect. Given the proper twist and correct bullet selection it will get the job done and handily.

I agree to shortgun's statement , the deer that I talked about was shot with a bullet that was way too light and a hollow point. It imploded that poor deer so bad that one could see it swell from impact.

The only way I personally would use a 22-250 on a deer is if i handloaded the specific loads. I have a 22-250 and I will be loading it possibly for that but I think that my 243 out shines the 22-250 for the larger animals like deer. I shoot 80 gr speers out of the 243 and it does wonders on deer and yotes alike. one bullet two different animals same gun. Alot of it will depend on if yoiu handload or not and if you have time to reset your scope. thats just my opinion happy hunting


ZGull

One can shoot equal weight bullets from a fast twist 22-250 barrels with better BC's. at equal speeds and wack deer handily. The 22-250 started life as a varmint cartridge but advancements in barrel and bullet technoligy have moved it up a notch to being a very effective deer caliber given the correct twist and proper bullet selection. An 80 grain .224 bullet running at about the same speed as a 80 gr .243 bullet is not likely to show much in the way of dimminshed on game performance. Better yet stick some TTSX's in that tube and squirt them out at 3600 FPS and one would be seriously amazed at what one could accomplish in the deer woods. If I do the same with my .22-250AI or my .250 savage AI and the .243 is left hangin by a serious amount in the bizzness of deer wackin.

Still boils down to puttin the RIGHT bullet in the RIGHT place and let them do the work.

I was having the same issue with these calibers, so I'm building one of each.