The difference is the length of the rail. Crossbows that are designed for 22 inch bolts are usually more front heavy. Ifyou compare the crossbows you will see that bows using 20 inch have a shorter stroke. If the crossbow is designed for 22 inch bolts that what you should use. Using the wrong size bolt in a crossbow can be dangerous and it definately effects accuracy. I have 3 crossbows. With the correct bolts I have them sighted for 45 yards, 55yards, 65 yards and 75 yards.